Natalie Clein's exceptional musicality has earned her a number of prestigious prizes including the Classical Brit Award for Young British Performer of 2005 and the Ingrid zu Solms Cultur Preis at the 2003 Kronberg Academie. She won the BBC Young Musician of the Year (aged 16) in 1994 and in the same year was the first ever British winner of the Eurovision Competition for Young Musicians in Warsaw. She was awarded the Queen Elizabeth the Queen Mother Scholarship by the Royal College of Music before completing her studies with Heinrich Schiff in Vienna.

She made her concerto debut at the BBC Proms in August 1997, performing the Haydn Cello Concerto in C major with Sir Roger Norrington and the National Youth Orchestra of Great Britain and has since appeared in venues throughout the UK such as the Royal Festival Hall, Barbican, Bridgewater Hall and Birmingham's Symphony Hall. She has performed as a soloist with most of the UK's major orchestras, including the London Philharmonic, Royal Philharmonic, City of Birmingham Symphony Orchestra, Bournemouth Symphony, The Philharmonia, Royal Scottish National, Hallé and BBC orchestras with conductors such as Sir Charles Mackerras, Gennardi Rozhdestvensky, Sir Andrew Davis, Heinrich Schiff, Sir Neville Marriner, and Paul Daniel.

Her international career continues to gain momentum with concerts in the United States, Canada, South America, Germany, Austria and Spain. She has given recitals in Tokyo, Seoul, New York (Lincoln Center) and Vienna and Salzburg. She is an avid chamber musician and each summer takes part in many of the world's great international festivals. Besides her regular recital partners - Julius Drake, Kathy Stott and Katya Apekisheva - her chamber music collaborations have included Martha Argerich, Ian Bostridge, Melvyn Tan, Imogen Cooper, Lars Vogt, Itamar Golan, Wayne Marshall, Steven Isserlis, clarinetists Michael Collins, Sharon Kam and Emma Johnson, oboist Nick Daniel and violinists Priya Mitchell, Pekka Kuusisto and Isabelle Faust.

Natalie records exclusively for EMI Classics. Her debut recording, a recital disc with both Brahms Cello Sonatas and Schubert's Arpeggione Sonata with Charles Owen was released in October 2004. She has since released ‘The Romantic Cello' with Charles Owen, which includes Rachmaninov's Sonata and Chopin's Sonata and Polonaise. Her latest disc of the Elgar Cello Concerto with the Royal Liverpool Philharmonic Orchestra and Vernon Handley, CBE conducting was released in September 2007.

Natalie Clein plays on the "Simpson" Guadagnini cello (1777).